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Article

Rational bases for the development of EGFR inhibitors for cancer treatment.

The international journal of biochemistry & cell biology - 1 Jan 2007

Bianco Roberto, Gelardi Teresa, Damiano Vincenzo, Ciardiello Fortunato, Tortora Giampaolo

Abstract excerpt

Growth factor receptors and their ligands not only regulate normal cell processes but have been also identified as key regulators of human cancer formation. The epidermal growth factor receptor (EGFR/ErbB1/HER1) belongs to the ErbB/HER-family of tyrosine kinase receptors (RTKs). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Several...

Topics

Antibodies, Monoclonal
Antineoplastic Agents
Cell Transformation, Neoplastic
Epidermal Growth Factor
ErbB Receptors
Humans
Mutation
Neoplasms
Protein-Tyrosine Kinases
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17596994
DOI: 10.1016/j.biocel.2007.05.008

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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