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Article

The epidermal growth factor receptor pathway: a model for targeted therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2006

Scaltriti Maurizio, Baselga José

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as a target for cancer therapy, and after 2 decades of intensive research, there are several anti-EGFR agents available in the clinic. Recent advances in our understanding in the mechanisms of receptor activation and function,...

Topics

ErbB Receptors
Extracellular Signal-Regulated MAP Kinases
Genes, ras
Humans
Models, Biological
Mutation
Oncogene Protein v-akt
Phosphatidylinositol 3-Kinases
STAT Transcription Factors
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

raf Kinases

src-Family Kinases

Source

Identifiers

PMID: 17000658
DOI: 10.1158/1078-0432.CCR-05-1554

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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