Article
The --174 G to C polymorphism of interleukin-6 gene is very rare in koreans.
Cytokine - 7 Jul 2002
Lim Chun Soo, Zheng Shouhuan, Kim Yon Su, Ahn Curie, Han Jin Suk, Kim Suhnggwon, Lee Jung Sang, Chae Dong-Wang
Abstract excerpt
The proinflammatory cytokine, interleukin-6 (IL-6), seems to be involved in the pathogenesis and progression of IgA nephropathy. Moreover, the transcriptional activity of the IL-6 gene and the plasma levels of IL-6 protein are associated with a single G/C base exchange polymorphism at position -174 of the IL-6 gene promoter. Using PCR-RFLP and PCR product sequencing, we examined the -174 polymorphism in 104 IgA...
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