Article
A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.
Molecular genetics and metabolism - 1 Jul 2008
Brorsson Caroline, Bergholdt Regine, Sjögren Marketa, Eising Stefanie, Sørensen Karina Meden, Hougaard David M, Orho-Melander Marju, Groop Leif, Pociot Flemming
Abstract excerpt
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1D), making this gene an interesting T1D...
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