The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency.

doi:10.1093/genetics/161.4.1395

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Article

The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency.

Genetics - 1 Aug 2002

Ito-Harashima Sayoko, Hartzog Phillip E, Sinha Himanshu, McCusker John H

Abstract excerpt

Extensive phenotypic diversity or variation exists in clonal populations of microorganisms and is thought to play a role in adaptation to novel environments. This phenotypic variation or instability, which occurs by multiple mechanisms, may be a form of cellular differentiation and a stochastic means for modulating gene expression. This work dissects a case of phenotypic variation in a clinically derived...

Topics

Genes, Suppressor
Genetic Variation
Membrane Proteins
Mutation
Phenotype
RNA, Transfer, Tyr
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 12196388
DOI: 10.1093/genetics/161.4.1395
PMCID: PMC1462226

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