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Article

Pairwise and higher-order genetic interactions during the evolution of a tRNA.

Nature - 1 Jun 2018

Domingo Júlia, Diss Guillaume, Lehner Ben

Abstract excerpt

A central question in genetics and evolution is the extent to which the outcomes of mutations change depending on the genetic context in which they occur1-3. Pairwise interactions between mutations have been systematically mapped within4-18 and between 19 genes, and have been shown to contribute substantially to phenotypic variation among individuals 20 . However, the extent to which genetic interactions...

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Identifiers

PMID: 29849145
DOI: 10.1038/s41586-018-0170-7
PMCID: PMC6193533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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