Article
Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma.
Neuro-oncology - 1 Aug 2009
Bryant Nichole L, Suarez-Cuervo Catalina, Gillespie G Yancey, Markert James M, Nabors L Burt, Meleth Sreelatha, Lopez Richard D, Lamb Lawrence S
Abstract excerpt
Classical immunotherapeutic approaches to glioblastoma multiforme (GBM) have shown mixed results, and therapies focused on innate lymphocyte activity against GBM have not been rigorously evaluated. We examined peripheral blood lymphocyte phenotype, gammadelta T-cell number, mitogenic response, and cytotoxicity against GBM cell lines and primary tumor explants from GBM patients at selected time points prior to and...
Topics
- Adult
- Aged
- Astrocytes
- Brain Neoplasms
- Case-Control Studies
- Cytokines
- Female
- Flow Cytometry
- Glioblastoma
- Humans
- Immunoenzyme Techniques