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Article

Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro.

Frontiers in immunology - 1 Jan 2023

Sivonen Minna, Sirviö Katja A, Wojciechowski Sara, Kailaanmäki Anssi, Kaipainen Satu, Bailey Aubrey, Villalba Martin, Kekarainen Tuija

Abstract excerpt

Objective: Natural killer (NK) cells are a part of the innate immune system and first-line defense against cancer. Since they possess natural mechanisms to recognize and kill tumor cells, NK cells are considered as a potential option for an off-the-shelf allogeneic cell-based immunotherapy. Here, our objective was to identify the optimal cytokine-based, feeder-free, activation and expansion protocol for cytotoxic...

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Identifiers

PMID: 37841273
DOI: 10.3389/fimmu.2023.1227064
PMCID: PMC10569479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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