Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

25 Oct 2002

Abstract excerpt

Nod2, a member of the Apaf1/Nod protein family, confers responsiveness to bacterial products and activates NF-kappaB, a transcription factor that plays a central role in innate immunity. Recently, genetic variation in Nod2 has been associated with susceptibility to Crohn's disease. Here, we report that expression of Nod2 is induced upon differentiation of CD34(+) hematopoietic progenitor cells into granulocyte or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to NF-κB Signaling Pathways
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12194982
DOI: 10.1074/jbc.m206473200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB ActivationPMID 12194982Read ↗

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.Semantic proximity Read ↗

Nod1 and Nod2 in innate immunity and human inflammatory disorders.Semantic proximity Read ↗

Insights into the molecular basis of the NOD2 signalling pathwaySemantic proximity Read ↗

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease.Semantic proximity Read ↗

Nod2 mutation enhances NF-kappa B activity and bacterial killing activity of macrophages.Semantic proximity Read ↗

Mucosal NOD2 expression and NF-kappaB activation in pediatric Crohn's disease.Semantic proximity Read ↗

Resolving the field: a role for Nod2 in T cells.Semantic proximity Read ↗

NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.Semantic proximity Read ↗

NODs: intracellular proteins involved in inflammation and apoptosis.Semantic proximity Read ↗

NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSemantic proximity Read ↗

MIP-3α expression in macrophages is NOD dependent.Semantic proximity Read ↗

NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.