Article
Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR.
Clinical chemistry - 1 Sept 2002
Koch Werner, Latz Wolfgang, Eichinger Marianne, Roguin Ariel, Levy Andrew P, Schömig Albert, Kastrati Adnan
Abstract excerpt
BACKGROUND: A genetically defined molecular heterogeneity of haptoglobin, characterized by the major phenotypic forms Hp 1-1, Hp 2-1, and Hp 2-2, has been associated with distinct clinical manifestations. To enable the use of DNA samples for the study of this polymorphism, we established a haptoglobin genotyping method based on PCR. METHODS: Taking advantage of the selectivity of PCR, we amplified DNA segments...
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