Article
A novel exonuclease (TaqMan) assay for rapid haptoglobin genotyping.
Clinical chemistry and laboratory medicine - 1 May 2016
Renner Wilfried, Jahrbacher Renate, Marx-Neuhold Ernestine, Tischler Simone, Zulus Barbara
Abstract excerpt
BACKGROUND: Haptoglobin is an acute-phase binding protein that scavenges free hemoglobin. The human haptoglobin gene (HP) is polymorphic with two main alleles, haptoglobin allele 1 (Hp1) and haptoglobin allele 2 (Hp2). The smaller Hp1 allele features no duplication and consists of four exons, whereas the larger Hp2 allele, containing a 1.7 kb duplication, consists of six exons, with the fifth and sixth being...
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