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Article

Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment.

Nature - 1 Jan 2023

Kachale Ambar, Pavlíková Zuzana, Nenarokova Anna, Roithová Adriana, Durante Ignacio M, Miletínová Petra, Záhonová Kristína, Nenarokov Serafim, Votýpka Jan, Horáková Eva, Ross Robert L, Yurchenko Vyacheslav, Beznosková Petra, Paris Zdeněk, Valášek Leoš Shivaya, Lukeš Julius

Abstract excerpt

Cognate tRNAs deliver specific amino acids to translating ribosomes according to the standard genetic code, and three codons with no cognate tRNAs serve as stop codons. Some protists have reassigned all stop codons as sense codons, neglecting this fundamental principle1-4. Here we analyse the in-frame stop codons in 7,259 predicted protein-coding genes of a previously undescribed trypanosomatid, Blastocrithidia...

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Identifiers

PMID: 36631608
DOI: 10.1038/s41586-022-05584-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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