Article
An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.
The EMBO journal - 1 Jul 1997
Fabrizio P, Laggerbauer B, Lauber J, Lane W S, Lührmann R
Abstract excerpt
The driving forces behind the many RNA conformational changes occurring in the spliceosome are not well understood. Here we characterize an evolutionarily conserved human U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116kD) that is strikingly homologous to the ribosomal elongation factor...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Cell Survival
- Conserved Sequence
- Cross-Linking Reagents
- DNA, Complementary
- Evolution, Molecular
- GTP-Binding Proteins
- Genes, Lethal
- Guanosine Triphosphate
- HeLa Cells
- Humans
- Mice
- Molecular Sequence Data
- Mutagenesis
- Peptide Elongation Factor 2