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Article

An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.

The EMBO journal - 1 Jul 1997

Fabrizio P, Laggerbauer B, Lauber J, Lane W S, Lührmann R

Abstract excerpt

The driving forces behind the many RNA conformational changes occurring in the spliceosome are not well understood. Here we characterize an evolutionarily conserved human U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116kD) that is strikingly homologous to the ribosomal elongation factor EF-2 (ribosomal translocase). A 114 kDa protein (Snu114p) homologous to U5-116kD was identified in Saccharomyces...

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Identifiers

PMID: 9233818
DOI: 10.1093/emboj/16.13.4092
PMCID: PMC1170032

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An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.PMID 9233818Read ↗

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