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Article

An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis.

BMC neurology - 21 Aug 2002

Niino Masaaki, Kikuchi Seiji, Fukazawa Toshiyuki, Miyagishi Ryuji, Yabe Ichiro, Tashiro Kunio

Abstract excerpt

BACKGROUND: The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome...

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Source

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Identifiers

PMID: 12188927
DOI: 10.1186/1471-2377-2-8
PMCID: PMC122076

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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