Article
Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis.
Journal of neuroimmunology - 1 Apr 2005
Osoegawa Manabu, Miyagishi Ryuji, Ochi Hirofumi, Nakamura Itta, Niino Masaaki, Kikuchi Seiji, Murai Hiroyuki, Fukazawa Toshiyuki, Minohara Motozumi, Tashiro Kunio, Kira Jun-Ichi
Abstract excerpt
We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The missense mutation A224D that impairs PAF-PAFR signaling was determined by polymerase chain...
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