Article
A study of promoter and intronic markers of ApoI/Fas gene and the interaction with Fas ligand in relapsing multiple sclerosis.
European neurology - 1 Jan 2004
Lucas Miguel, Zayas María D, De Costa Alzenira F, Solano Francisca, Chadli Amal, Dinca Luminita, Izquierdo Guillermo
Abstract excerpt
We studied the association between multiple sclerosis (MS) and a novel single nucleotide polymorphism (SNP), A/T(735)G/C, localized in intron IV of the ApoI/Fas gene, which is recognized by the restrictase MaeI. Fas-MaeI genotypes were screened in chromosomes of 215 healthy individuals and 312 relapsing MS patients of Spanish extraction. We also analyzed the interaction of this new intragenic marker with others...
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