Article
The FAS-670 polymorphism influences susceptibility to multiple sclerosis.
Journal of neuroimmunology - 1 Jul 2002
van Veen T, Kalkers N F, Crusius J B A, van Winsen L, Barkhof F, Jongen P J H, Peña A S, Polman C H, Uitdehaag B M J
Abstract excerpt
Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS-670 polymorphism in 382 patients with MS and 206 controls, and found that the carriership of allele FAS-670*G was significantly less frequent in patients than in controls. We found no association between the...
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