Physical mapping of the minimal region of loss in 5q- chromosome.

doi:10.1073/pnas.92.16.7406

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Article

Physical mapping of the minimal region of loss in 5q- chromosome.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995

Fairman J, Chumakov I, Chinault A C, Nowell P C, Nagarajan L

Abstract excerpt

Acquired interstitial loss of all or part of the long arm of human chromosome 5 (5q-) is an anomaly that is seen frequently in patients with preleukemic myelodysplasia and acute myelogenous leukemia. Loss of a critical region of overlap at band 5q31.1 in all of these cases, with various cytogenetic breaks, signifies the existence of a key negative regulator of leukemogenesis. Previous studies have defined the...

Topics

Alleles
Chromosome Deletion
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 5
Female
Genes, Tumor Suppressor
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukemia, Myeloid, Acute

Middle Aged

Oligodeoxyribonucleotides

Polymorphism, Restriction Fragment Length

Repetitive Sequences, Nucleic Acid

Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7638206
DOI: 10.1073/pnas.92.16.7406
PMCID: PMC41348

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7638206-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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