Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility gene for familial acute myeloid leukemia associated with loss of 5q and/or 7q is not localized on the commonly deleted portion of 5q.

Genes, chromosomes & cancer - 1 Jun 2000

Gao Q, Horwitz M, Roulston D, Hagos F, Zhao N, Freireich E J, Golomb H M, Olopade O I

Abstract excerpt

The molecular mechanism for the occurrence of leukemia in multiple members of a family has not been fully elucidated but data support the contribution of highly penetrant mutations in leukemia susceptibility genes. We have investigated the genetic etiology of an unusual three-generation family with apparent autosomal dominant transmission of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 16

Share to Chromosomes, Human, Pair 5

Share to Chromosomes, Human, Pair 7

Share to Karyotyping

Share to Leukemia, Myeloid

Share to Loss of Heterozygosity

Source

Identifiers

PMID: 10825001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility gene for familial acute myeloid leukemia associated with loss of 5q and/or 7q is not localized on the commonly deleted portion of 5q.PMID 10825001Read ↗

Delineation of a minimal interval and identification of 9 candidates for a tumor suppressor gene in malignant myeloid disorders on 5q31Semantic proximity Read ↗

Physical mapping of the minimal region of loss in 5q- chromosome.Semantic proximity Read ↗

Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1–1.5 Mb and preparation of a PAC-based physical mapSemantic proximity Read ↗

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.Semantic proximity Read ↗

Deletions of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms.Semantic proximity Read ↗

Transcript Map and Comparative Analysis of the 1.5-Mb Commonly Deleted Segment of Human 5q31 in Malignant Myeloid Diseases with a del(5q)Semantic proximity Read ↗

Absence of allelic loss on chromosome 5q by RFLP analysis in preleukemia.Semantic proximity Read ↗

Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60.Semantic proximity Read ↗

Analysis of expressed sequence tags mapping to the critical region of the 5q syndromeSemantic proximity Read ↗

Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited.Semantic proximity Read ↗

Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell levelSemantic proximity Read ↗

Is monosomy 5 an uncommon aberration? Fluorescence in situ hybridization reveals translocations and deletions in myelodysplastic syndromes or acute myelocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.