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Article

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.

The Journal of physiology - 15 Aug 2003

Lu Yu, Mahaut-Smith Martyn P, Huang Christopher L-H, Vandenberg Jamie I

Abstract excerpt

Mutations in KCNE2, which encodes the minK-related protein 1 (MiRP1), are associated with an increased risk of arrhythmias; however, the underlying mechanisms are unknown. MiRP1 is thought to associate with many K+ channel alpha-subunits, including HERG K+ channels, which have a major role in suppressing arrhythmias initiated by premature beats. In this study we have investigated in Chinese hamster ovary (CHO)...

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Identifiers

PMID: 12923204
DOI: 10.1113/jphysiol.2003.046045
PMCID: PMC2343156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.PMID 12923204Read ↗

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