Article
The interleukin-6 G(-174)C promoter polymorphism in the LURIC cohort: no association with plasma interleukin-6, coronary artery disease, and myocardial infarction.
Journal of molecular medicine (Berlin, Germany) - 1 Aug 2002
Nauck Markus, Winkelmann Bernhard R, Hoffmann Michael M, Böhm Bernhard O, Wieland Heinrich, März Winfried
Abstract excerpt
IL-6 plasma levels are predictive of major cardiovascular events. Recently a G/C polymorphism at position -174 in the promoter of the IL-6 gene has been associated with differences in both the IL-6 transcription rate in vitro and IL-6 levels in vivo. We examined the association of this polymorphism with coronary artery disease (CAD) and previous myocardial infarction (MI) in 2559 patients with angiographically...
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