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Article

Interleukin 6 -174 g/c promoter polymorphism and risk of coronary heart disease: results from the rotterdam study and a meta-analysis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2006

Sie Mark P S, Sayed-Tabatabaei Fakhredin A, Oei Hok-Hay S, Uitterlinden André G, Pols Hubert A P, Hofman Albert, van Duijn Cornelia M, Witteman Jacqueline C M

Abstract excerpt

OBJECTIVE: Inflammation plays a pivotal role in the pathogenesis of atherosclerosis. Interleukin (IL) 6 has many inflammatory functions, and the IL-6 -174 G/C promoter polymorphism appears to influence IL-6 levels. Findings of previous studies on the relation between this polymorphism and risk of cardiovascular diseases are inconsistent. We investigated this polymorphism in relation to risk of coronary heart...

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Identifiers

PMID: 16269662
DOI: 10.1161/01.ATV.0000194099.65024.17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interleukin 6 -174 g/c promoter polymorphism and risk of coronary heart disease: results from the rotterdam study and a meta-analysis.PMID 16269662Read ↗

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The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men.Semantic proximity Read ↗

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Lack of an association between interleukin-6 -174G/C polymorphism and circulating interleukin-6 levels in normal population: a meta-analysis.Semantic proximity Read ↗

Polymorphisms of -174G>C and -572G>C in the interleukin 6 (IL-6) gene and coronary heart disease risk: a meta-analysis of 27 research studies.Semantic proximity Read ↗

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