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Article

Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein.

The Journal of pharmacology and experimental therapeutics - 1 Sept 2002

Ohashi Rikiya, Tamai Ikumi, Inano Akihiro, Katsura Masaki, Sai Yoshimichi, Nezu Jun-ichi, Tsuji Akira

Abstract excerpt

The organic cation/carnitine transporter OCTN2 mediates transport of carnitine and organic cations in Na(+)-dependent and Na(+)-independent manners, respectively. However, the mechanism of molecular recognition of different substrates has not been clarified yet. We previously found a single amino acid change in OCTN2, Ser467Cys (S467C), in the Japanese population and observed a decreased carnitine transport but...

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PMID: 12183691
DOI: 10.1124/jpet.102.036004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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