Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance.

Antimicrobial agents and chemotherapy - 1 Sept 2002

Moran Gary, Sullivan Derek, Morschhäuser Joachim, Coleman David

Abstract excerpt

The present study investigated the role of the Candida dubliniensis CdCDR1 and CdCDR2 genes in the development of fluconazole resistance. The C. dubliniensis CdCDR1 gene was 92% identical at the nucleotide sequence level to the corresponding C. albicans gene. However, 58% (14 of 24) of C. dubliniensis genotype 1 isolates tested harbored a nonsense mutation in the CdCDR1 open reading frame that converted codon 756...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Azoles

Share to Candida

Share to Drug Resistance, Fungal

Share to Fluconazole

Share to Gene Targeting

Share to Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12183235
DOI: 10.1128/AAC.46.9.2829-2841.2002
PMCID: PMC127416

Genes

TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance.PMID 12183235Read ↗

Identification and Expression of Multidrug Transporters Responsible for Fluconazole Resistance in Candida dubliniensisSemantic proximity Read ↗

Reduced azole susceptibility in genotype 3 Candida dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression.Semantic proximity Read ↗

Comparison of the epidemiology, drug resistance mechanisms, and virulence of andSemantic proximity Read ↗

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals.Semantic proximity Read ↗

Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains.Semantic proximity Read ↗

Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.Semantic proximity Read ↗

MDR1-mediated drug resistance in Candida dubliniensis.Semantic proximity Read ↗

The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans.Semantic proximity Read ↗

A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazoleSemantic proximity Read ↗

Candida dubliniensis: ten years on.Semantic proximity Read ↗

Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation.Semantic proximity Read ↗

Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.