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Article

How microchimerism can impart HLA susceptibility in patients with rheumatoid arthritis.

Chimerism - 1 Jan 2000

Azzouz Doua F, Rak Justyna M, Balandraud Nathalie, Auger Isabelle, Martin Marielle, Roudier Jean, Lambert Nathalie C

Abstract excerpt

Rheumatoid arthritis, a chronic inflammatory joint disease, is strongly associated with HLA-DRB1*01 and *04 alleles that have in common similar 5-amino acid motifs in the third hypervariable region of DRB1 (QKRAA, QRRAA, RRRAA), the so called shared epitope (SE). Most patients with RA carry 1 or 2 doses of the SE, with particular genetic combinations at higher risk. In recent work we provided evidence that...

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Identifiers

PMID: 21327148
DOI: 10.4161/chim.1.1.12648
PMCID: PMC3035110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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