Article
Population genetics of rheumatoid arthritis.
Rheumatic diseases clinics of North America - 1 Nov 1992
Ollier W, Thomson W
Abstract excerpt
A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hyper-variable region of the molecule. This "shared epitope" is found on various DR4, DR1, and DR6 varia...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Base Sequence
- DNA
- Epitopes
- Genetic Predisposition to Disease
- Genetics, Population
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans