Article
Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast.
The Journal of biological chemistry - 10 Nov 2000
Zhang Y, Sugiura R, Lu Y, Asami M, Maeda T, Itoh T, Takenawa T, Shuntoh H, Kuno T
Abstract excerpt
The ppb1(+) gene encodes a fission yeast homologue of the mammalian calcineurin. We have recently shown that Ppb1 is essential for chloride ion homeostasis, and acts antagonistically with Pmk1 mitogen-activated protein kinase pathway. In an attempt to identify genes that share an essential function with calcineurin, we screened for mutations that confer sensitivity to the calcineurin inhibitor FK506 and high...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.