Article
Calcineurin is implicated in the regulation of the septation initiation network in fission yeast.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2002
Lu Yabin, Sugiura Reiko, Yada Tomoko, Cheng Hong, Sio Susie O, Shuntoh Hisato, Kuno Takayoshi
Abstract excerpt
BACKGROUND: In fission yeast, calcineurin has been implicated in cytokinesis because calcineurin-deleted cells form multiple septa and cell separation is impeded. However, this mechanism remains unclear. RESULTS: We screened for mutations that confer synthetic lethality with calcineurin deletion and isolated a mutant, its 10-1/cdc7-i10, a novel allele of the cdc7+ gene involved in the septation initiation network...
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