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Article

Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities.

Oncotarget - 27 Dec 2016

Gagné Jean-Philippe, Lachapelle Sophie, Garand Chantal, Tsofack Serges P, Coulombe Yan, Caron Marie-Christine, Poirier Guy G, Masson Jean-Yves, Lebel Michel

Abstract excerpt

Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients (WRN) is a helicase/exonuclease involved in DNA replication and repair. Here, we present the results of a large-scale proteome analysis that has been undertaken to determine protein partners of different polymorphic WRN proteins found with relatively high...

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Source

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Identifiers

PMID: 27863399
DOI: 10.18632/oncotarget.13341
PMCID: PMC5349866

Genes

WRN
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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