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Article

Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2000

Niwa K, Younkin L, Ebeling C, Turner S K, Westaway D, Younkin S, Ashe K H, Carlson G A, Iadecola C

Abstract excerpt

Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide (Abeta), play a critical role in the pathogenesis of Alzheimer's dementia. We report that transgenic mice overexpressing APP and Abeta have a profound attenuation in the in...

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Identifiers

PMID: 10944232
DOI: 10.1073/pnas.97.17.9735
PMCID: PMC16934

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10944232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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