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Article

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2002

Dorne J L C M, Walton K, Slob W, Renwick A G

Abstract excerpt

Human variability in the kinetics of CYP2D6 substrates has been quantified using a database of compounds metabolised extensively (>60%) by this polymorphic enzyme. Published pharmacokinetic studies (after oral and intravenous dosing) in non-phenotyped healthy adults, and phenotyped extensive (EMs), intermediate or slow-extensive (SEMs) and poor metabolisers (PMs) have been analysed using data for parameters that...

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PMID: 12176090
DOI: 10.1016/s0278-6915(02)00117-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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