Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism.

Journal of clinical pharmacy and therapeutics - 1 Jun 2011

Baek I H, Kang W, Yun H Y, Lee S S, Kwon K I

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: This study aimed to model the atypical absorption of menatetrenone and its epoxide metabolite and to examine the influence of the single nucleotide polymorphism (SNP) of vitamin K2 epoxide reductase complex subunit 1 (VKORC1) on the pharmacokinetics. METHODS: After the administration of 30 mg of menatetrenone to 26 healthy subjects, the plasma concentrations of menatetrenone and its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Epoxy Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Half-Life

Share to Intestinal Absorption

Share to Mixed Function Oxygenases

Share to Republic of Korea

Share to Vitamin K 2

Share to Vitamin K Epoxide Reductases

Source

Identifiers

PMID: 21545618
DOI: 10.1111/j.1365-2710.2010.01183.x

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism.PMID 21545618Read ↗

CYP2C9 and VKORC1 in therapeutic dosing and safety of acenocoumarol treatment: implication for clinical practice in Hungary.Semantic proximity Read ↗

Warfarin and vitamin K intake in the era of pharmacogenetics.Semantic proximity Read ↗

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?Semantic proximity Read ↗

The pediatric acenocoumarol dosing algorithm: the Children Anticoagulation and Pharmacogenetics Study.Semantic proximity Read ↗

An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population.Semantic proximity Read ↗

A model predicting fluindione dose requirement in elderly inpatients including genotypes, body weight, and amiodarone.Semantic proximity Read ↗

Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians.Semantic proximity Read ↗

The Pharmacokinetics of Vitamin CSemantic proximity Read ↗

A pharmacokinetic-pharmacodynamic model for predicting the impact of CYP2C9 and VKORC1 polymorphisms on fluindione and acenocoumarol during induction therapy.Semantic proximity Read ↗

Pharmacogenetics of acenocoumarol in patients with extreme dose requirements.Semantic proximity Read ↗

Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors.Semantic proximity Read ↗

Genotype-based dosage of acenocoumarol in highly-sensitive geriatric patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.