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Article

Polymorphic CYP2C19 and N-acetylation: human variability in kinetics and pathway-related uncertainty factors.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Feb 2003

Dorne J L C M, Walton K, Renwick A G

Abstract excerpt

CYP2C19-mediated oxidation and N-acetylation constitute major phase I and phase II polymorphic pathways of xenobiotic metabolism in humans. Analysis of human variability in kinetics for these pathways has been carried out for compounds metabolised extensively (>60%) by these routes. Data for minor substrates for CYP2C19 metabolism (10-60%) have also been analysed. Published pharmacokinetic studies (after oral and...

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Identifiers

PMID: 12480299
DOI: 10.1016/s0278-6915(02)00210-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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