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Article

Characterization and resistance mechanisms of a 5-fluorouracil- resistant hepatocellular carcinoma cell line.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Gu Wei, Fang Fan-Fu, Li Bai, Cheng Bin-Bin, Ling Chang-Quan

Abstract excerpt

PURPOSE: The chemoresistance of human hepatocellular carcinoma (HCC) to cytotoxic drugs, especially intrinsic or acquired multidrug resistance (MDR), still remains a major challenge in the management of HCC. In the present study, possible mechanisms involved in MDR of HCC were identified using a 5-fluorouracil (5-FU) -resistant human HCC cell line. METHODS: BEL-7402/5-FU cells were established through continuous...

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PMID: 23167424
DOI: 10.7314/apjcp.2012.13.9.4807

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