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Article

Developmental paradigms in heart disease: insights from tinman.

Annals of medicine - 1 Jan 2002

Prall Owen W J, Elliott David A, Harvey Richard P

Abstract excerpt

Congenital heart disease is a significant cause of morbidity and mortality in humans, and gene mutations that underlie some of these anomalies are now being described. The NKX2.5 gene, which encodes a homeobox transcription factor, was initially discovered in mice through its similarity to the tinman gene of the fruitfly Drosophila. Tinman is required for formation of the dorsal pulsatile vessel or 'heart' of the...

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Identifiers

PMID: 12173684

Genes

TBX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Developmental paradigms in heart disease: insights from tinman.PMID 12173684Read ↗

Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.Semantic proximity Read ↗

Using Drosophila to model a variant of unknown significance in the human cardiogenic gene <i>Nkx2.5</i>Semantic proximity Read ↗

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.Semantic proximity Read ↗

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.Semantic proximity Read ↗

Congenital heart diseases and their association with the variant distribution features on susceptibility genes.Semantic proximity Read ↗

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Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis.Semantic proximity Read ↗

Congenital heart disease caused by mutations in the transcription factor NKX2-5.Semantic proximity Read ↗

Transcription factor neuromancer/TBX20 is required for cardiac function in <i>Drosophila</i> with implications for human heart diseaseSemantic proximity Read ↗

Genetics of Congenital Heart Defects: The NKX2-5 Gene, a Key PlayerSemantic proximity Read ↗

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A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and DiseaseSemantic proximity Read ↗

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