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Article

Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.

Developmental biology - 1 Jan 2021

Howard Austin M, Milner Hayley, Hupp Madison, Willett Courtney, Palermino Kristina, Nowak Scott J

Abstract excerpt

The regulation of formation of the Drosophila heart by the Nkx 2.5 homologue Tinman is a key event during embryonic development. In this study, we identify the highly conserved transcription cofactor Akirin as a key factor in the earliest induction of tinman by the Twist transcription cofactor. akirin mutant embryos display a variety of morphological defects in the heart, including abnormal spacing between rows...

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Identifiers

PMID: 32950464
DOI: 10.1016/j.ydbio.2020.09.001
PMCID: PMC7722205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.PMID 32950464Read ↗

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