Article
Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.
Developmental biology - 1 Dec 1998
Grow M W, Krieg P A
Abstract excerpt
In Drosophila, the tinman gene is absolutely required for development of the dorsal vessel, the insect equivalent of the heart. In vertebrates, the tinman gene is represented by a small family of tinman-related sequences, some of which are expressed during embryonic heart development. At present...
Topics
- Animals
- Cell Differentiation
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Dominant
- Heart
- Homeobox Protein Nkx-2.5
- Homeodomain Proteins
- Mutation
- Repressor Proteins
- Trans-Activators
- Transcription Factors
- Xenopus
- Xenopus Proteins