Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.

Development (Cambridge, England) - 1 Oct 2006

Zaffran Stéphane, Reim Ingolf, Qian Li, Lo Patrick C, Bodmer Rolf, Frasch Manfred

Abstract excerpt

The NK homeobox gene tinman (tin) is required for the specification of the cardiac, visceral muscle and somatic muscle progenitors in the early dorsal mesoderm of Drosophila. Like its vertebrate counterpart Nkx2.5, the expression of tin is maintained in cardiac cells during cardiac maturation and differentiation; however, owing to the complete lack of a dorsal vessel in tin mutant embryos, the function of tin in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Genes, Homeobox

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesoderm

Share to Myocardium

Share to Trans-Activators

Share to Ventricular Remodeling

Source

Identifiers

PMID: 16987868
DOI: 10.1242/dev.02586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.PMID 16987868Read ↗

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.Semantic proximity Read ↗

Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.Semantic proximity Read ↗

The gene tinman is required for specification of the heart and visceral muscles in Drosophila.Semantic proximity Read ↗

The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart.Semantic proximity Read ↗

Developmental paradigms in heart disease: insights from tinman.Semantic proximity Read ↗

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila.Semantic proximity Read ↗

A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development.Semantic proximity Read ↗

Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila.Semantic proximity Read ↗

The NK homeodomain transcription factor Tinman is a direct activator of seven-up in the Drosophila dorsal vessel.Semantic proximity Read ↗

Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis.Semantic proximity Read ↗

tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman.Semantic proximity Read ↗

The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.