Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.

European journal of human genetics : EJHG - 1 Sept 2002

Vakkilainen Juha, Pajukanta Päivi, Cantor Rita M, Nuotio Ilpo O, Lahdenperä Sanni, Ylitalo Kati, Pihlajamäki Jussi, Kovanen Petri T, Laakso Markku, Viikari Jorma S A, Peltonen Leena, Taskinen Marja-Riitta

Abstract excerpt

The nature of the genetic and environmental factors influencing low density lipoprotein (LDL) particle size in patients with familial combined hyperlipidaemia (FCHL) is under debate. We measured LDL peak particle size in 553 subjects belonging to 48 Finnish FCHL families. Individuals with high triglyceride (TG) concentrations (phenotype IV) or combined hyperlipidaemia (phenotype IIB) had significantly smaller LDL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, HDL
Share to Finland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypercholesterolemia

Share to Hyperlipidemia, Familial Combined

Share to Lipoproteins, LDL

Share to Molecular Weight

Share to Regression Analysis

Share to Triglycerides

Source

Identifiers

PMID: 12173032
DOI: 10.1038/sj.ejhg.5200844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.PMID 12173032Read ↗

Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia.Semantic proximity Read ↗

Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan.Semantic proximity Read ↗

Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter.Semantic proximity Read ↗

Pleiotropic genetic effects contribute to the correlation between HDL cholesterol, triglycerides, and LDL particle size in hypertensive sibships.Semantic proximity Read ↗

Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype.Semantic proximity Read ↗

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.Semantic proximity Read ↗

Heritability of LDL peak particle diameter in the Quebec Family Study.Semantic proximity Read ↗

Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter.Semantic proximity Read ↗

Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men.Semantic proximity Read ↗

Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype.Semantic proximity Read ↗

Genotype of the mutant LDL receptor allele is associated with LDL particle size heterogeneity in familial hypercholesterolemia.Semantic proximity Read ↗

Lipoprotein lipase gene mutations D9N and N291S in four pedigrees with familial combined hyperlipidaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.