Article
Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype.
American journal of human genetics - 1 Aug 1998
Allayee H, Aouizerat B E, Cantor R M, Dallinga-Thie G M, Krauss R M, Lanning C D, Rotter J I, Lusis A J, de Bruin T W
Abstract excerpt
Small, dense LDL particles consistently have been associated with hypertriglyceridemia, premature coronary artery disease (CAD), and familial combined hyperlipidemia (FCH). Previously, we have observed linkage of LDL particle size with four separate candidate-gene loci in a study of families enri...
Topics
- Adult
- Apolipoprotein A-I
- Apolipoprotein C-II
- Apolipoproteins A
- Apolipoproteins C
- Carrier Proteins
- Cholesterol Ester Transfer Proteins
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 16
- Chromosomes, Human, Pair 19
- Chromosomes, Human, Pair 6
- Coronary Disease