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Article

Pleiotropic genetic effects contribute to the correlation between HDL cholesterol, triglycerides, and LDL particle size in hypertensive sibships.

American journal of hypertension - 1 Jan 2005

Kullo Iftikhar J, de Andrade Mariza, Boerwinkle Eric, McConnell Joseph P, Kardia Sharon L R, Turner Stephen T

Abstract excerpt

OBJECTIVE: Abnormalities of HDL cholesterol (HDL-C), triglycerides, and LDL particle size are present in familial dyslipidemic hypertension. We investigated heritability of these three lipid traits and the extent to which shared effects of genes (pleiotropy) contribute to the additive genetic variation in each trait in hypertensive sibships. METHODS: Subjects included 788 individuals (60% women) ascertained...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15691623
DOI: 10.1016/j.amjhyper.2004.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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