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Article

Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.

Gut - 1 Feb 2004

Crabtree M D, Fletcher C, Churchman M, Hodgson S V, Neale K, Phillips R K S, Tomlinson I P M

Abstract excerpt

BACKGROUND: We have recently shown that the severity of human colonic familial adenomatous polyposis (FAP) varies in a manner consistent with the action of modifier genes. These modifier genes may harbour common alleles which increase the risk of colorectal cancer (CRC) in the general population. Analyses have suggested several common polymorphisms as risk alleles for CRC. METHODS: We determined the association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14724163
DOI: 10.1136/gut.2003.015586
PMCID: PMC1774929

Genes

NAT1
FAP
NAT2
APC
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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