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Article

Wild-type APC Influences the Severity of Familial Adenomatous Polyposis

10 Nov 2021

Abstract excerpt

Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP). FAP patients develop multiple colonic adenomas early in life. The number of polyps can vary considerably because of different mutations1 but also for family members carrying the same mutation.2 Several genes have been considered as modifiers for the intrafamilial severity differences.3

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PMID: 34774804
DOI: 10.1016/j.jcmgh.2021.11.002

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