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Article

Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.

The EMBO journal - 15 Aug 2002

Kami Keiichiro, Takeya Ryu, Sumimoto Hideki, Kohda Daisuke

Abstract excerpt

The basic function of the Src homology 3 (SH3) domain is considered to be binding to proline-rich sequences containing a PxxP motif. Recently, many SH3 domains, including those from Grb2 and Pex13p, were reported to bind sequences lacking a PxxP motif. We report here that the 22 residue peptide lacking a PxxP motif, derived from p47(phox), binds to the C-terminal SH3 domain from p67(phox). We applied the NMR...

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Share to CSK Tyrosine-Protein Kinase
Share to GRB2 Adaptor Protein
Share to NADPH Oxidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12169629
DOI: 10.1093/emboj/cdf428
PMCID: PMC126167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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