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Article

HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8 <sup>+</sup> cytolytic T lymphocytes

5 Sept 2003

Abstract excerpt

HLA-E-restricted T cell receptor alphabeta+ CD8+ cytolytic T lymphocytes (CTLs) exist as monoclonal expansions in the peripheral blood of some individuals. Here, we show that they recognize, with high avidity, peptides derived from the UL40 protein of different human cytomegalovirus (CMV) strains. Recognition results in the induction of cytotoxicity, IFN-gamma production and cell proliferation. Autologous cells...

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PMID: 12960383
DOI: 10.1073/pnas.1834449100

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HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8 <sup>+</sup> cytolytic T lymphocytesPMID 12960383Read ↗

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