Article
HLA-E-restricted cross-recognition of allogeneic endothelial cells by CMV-associated CD8 T cells: a potential risk factor following transplantation.
PloS one - 1 Jan 2012
Allard Mathilde, Tonnerre Pierre, Nedellec Steven, Oger Romain, Morice Alexis, Guilloux Yannick, Houssaint Elisabeth, Charreau Béatrice, Gervois Nadine
Abstract excerpt
Although association between CMV infection and allograft rejection is well admitted, the precise mechanisms involved remain uncertain. Here, we report the characterization of an alloreactive HLA-E-restricted CD8 T cell population that was detected in the PBL of a kidney transplant patient after its CMV conversion. This monoclonal CD8 T cell population represents a sizable fraction in the blood (3% of PBL) and is...
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