Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model

28 Sept 2005

Abstract excerpt

To identify candidate genes that may be involved in motoneuron degeneration, we combined laser capture microdissection with microarray technology. Gene expression in motoneurons was analyzed during the progression of the disease in transgenic SOD1(G93A) mice that develop motoneuron loss. Three major observations were made: first, there was only a small number of genes that were differentially expressed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to RNA Research and Splicing
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16192287
DOI: 10.1093/hmg/ddi357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse modelPMID 16192287Read ↗

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosisSemantic proximity Read ↗

Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALSSemantic proximity Read ↗

Early gene expression changes in spinal cord from SOD1G93A Amyotrophic Lateral Sclerosis animal modelSemantic proximity Read ↗

Investigating cell death mechanisms in amyotrophic lateral sclerosis using transcriptomicsSemantic proximity Read ↗

Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse modelSemantic proximity Read ↗

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.Semantic proximity Read ↗

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Differential gene expression in the axotomized facial motor nucleus of presymptomatic SOD1 mice.Semantic proximity Read ↗

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.Semantic proximity Read ↗

Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis.Semantic proximity Read ↗

Transcriptional profile of primary astrocytes expressing ALS‐linked mutant SOD1Semantic proximity Read ↗

Gene Expressions Specifically Detected in Motor Neurons (Dynactin 1, Early Growth Response 3, Acetyl-CoA Transporter, Death Receptor 5, and Cyclin C) Differentially Correlate to Pathologic Markers in Sporadic Amyotrophic Lateral SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.