Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.

Brain : a journal of neurology - 1 Feb 2011

Kirby Janine, Ning Ke, Ferraiuolo Laura, Heath Paul R, Ismail Azza, Kuo Su-Wei, Valori Chiara F, Cox Laura, Sharrack Basil, Wharton Stephen B, Ince Paul G, Shaw Pamela J, Azzouz Mimoun

Abstract excerpt

Gene expression profiling has been used previously with spinal cord homogenates and laser capture microdissected motor neurons to determine the mechanisms involved in neurodegeneration in amyotrophic lateral sclerosis. However, while cellular and animal model work has focused on superoxide dismutase 1-related amyotrophic lateral sclerosis, the transcriptional profile of human mutant superoxide dismutase 1 motor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lentivirus

Share to Motor Neurons

Share to Nerve Degeneration

Share to Phosphatidylinositol 3-Kinase

Share to PTEN Phosphohydrolase

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 21228060
DOI: 10.1093/brain/awq345
PMCID: PMC3030763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.PMID 21228060Read ↗

Investigating cell death mechanisms in amyotrophic lateral sclerosis using transcriptomicsSemantic proximity Read ↗

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosisSemantic proximity Read ↗

Molecular biology of amyotrophic lateral sclerosis: insights from genetics.Semantic proximity Read ↗

Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALSSemantic proximity Read ↗

Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegenerationSemantic proximity Read ↗

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

ALS: a disease of motor neurons and their nonneuronal neighbors.Semantic proximity Read ↗

Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis.Semantic proximity Read ↗

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosisSemantic proximity Read ↗

Transcriptional profile of primary astrocytes expressing ALS‐linked mutant SOD1Semantic proximity Read ↗

Differential gene expression in patients with amyotrophic lateral sclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.