Article
A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung.
Journal of epidemiology - 1 May 2002
Ito Hidemi, Hamajima Nobuyuki, Takezaki Toshiro, Matsuo Keitaro, Tajima Kazuo, Hatooka Shunzo, Mitsudomi Tetsuya, Suyama Motokazu, Sato Shigeki, Ueda Ryuzo
Abstract excerpt
The 8-oxoguanine DNA glycosylase (OGG1) repairs DNA by removing 8-hydroxyguanine, a highly mutagenic oxidative DNA adduct. Recently, the gene for OGG1 was cloned and several polymorphisms have been reported. Because environmental carcinogens produce 8-hydroxyguanine residues that potentially cause oncogenic mutations by mismatching to this modified base, the capacity to repair these lesions can be involved in...
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