Article
Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk.
Cancer science - 1 Aug 2006
Kohno Takashi, Kunitoh Hideo, Toyama Kaoru, Yamamoto Seiichiro, Kuchiba Aya, Saito Daizo, Yanagitani Noriko, Ishihara Shin-ichi, Saito Ryusei, Yokota Jun
Abstract excerpt
Adenocarcinoma (ADC) is the most frequent histological type of lung cancer and comprises the majority of lung cancers in non-smokers. Thus, genetic factors responsible for ADC susceptibility need to be determined to establish efficient ways of preventing the disease. The OGG1 gene, encoding a glycosylase for 8-hydroxyguanine, an oxidatively damaged promutagenic base, has the polymorphism Ser326Cys, and...
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